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Organidin Side Effects, and Drug Interactions - Guaifenesin (oral)

Organidin Side Effects, and Drug Interactions - Guaifenesin (oral)

SIDE EFFECTS

Guaifenesin is well tolerated and has a wide margin of safety. Side effects have been generally mild and infrequent. Nausea and vomiting are the side effects that occur most commonly. Dizziness, headache, and rash (including urticaria) have been reported rarely.

Codeine [TUSSI-ORGANIDIN® NR* (* Newly Reformulated)]: Nausea, vomiting, constipation, drowsiness, and miosis have been reported. Higher doses may induce euphoria, light- headedness, dizziness, drowsiness and depression of respiration. Pruritus and skin rashes have been rare.

Dextromethorphan [TUSSI-ORGANIDIN® DM NR* (* Newly Reformulated)]: Rare drowsiness or mild gastrointestinal disturbances are the only side effects associated with dextromethorphan in clinical use (see also

DRUG INTERACTIONS

).

DRUG ABUSE AND DEPENDENCE

TUSSI-ORGANIDIN® NR* (* Newly Reformulated) Liquid: Controlled Substance— Schedule V Dependence— Codeine may be habit-forming.

DRUG INTERACTIONS

TUSSI-ORGANIDIN® NR* (* Newly Reformulated): The use of codeine may result in additive CNS depressant effects when coadministered with alcohol, antihistamines, psychotropics or other drugs that produce CNS depression.

TUSSI-ORGANIDIN® DM NR* (* Newly Reformulated): Serious toxicity may result if dextromethorphan is coadministered with monoamine oxidase inhibitors (MAOIs). The use of dextromethorphan hydrobromide may result in additive CNS depressant effects when coadministered with alcohol, antihistamines, psychotropics or other drugs that produce CNS depression.

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