A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Factrel Side Effects, and Drug Interactions - gonadorelin
Factrel Side Effects, and Drug Interactions - gonadorelin
SIDE EFFECTS
Systemic effects have been reported rarely following administration of 100
mcg of Factrel.
CNS: headache, light-headedness.
GI: nausea, abdominal discomfort.
Dermatologic: local swelling, occasionally with pain and
pruritis, at the injection site may occur following subcutaneous administration;
local and generalized skin rash have been noted after chronic subcutaneous administration.
Cardiovascular: flushing.
Rare instances of hypersensitivity reaction (bronchospasm, tachycardia, flushing,
urticaria, induration at injection site) and anaphylactic reactions have been
reported following multiple-dose administration.
There has been a report of pituitary apoplexy and sudden blindness following
gonadotropin-releasing hormone administration to a patient with a gonadotropin-secreting
adenoma.
DRUG INTERACTIONS
The Factrel test should be conducted in the absence of other drugs which directly
affect the pituitary secretion of the gonadotropins. These would include a variety
of preparations which contain androgens, estrogens, progestins, or glucocorticoids.
The gonadotropin levels may be transiently elevated by spironolactone, minimally
elevated by levodopa, and suppressed by oral contraceptives and digoxin. The
response to Factrel may be blunted by phenothiazines and dopamine antagonists
which cause a rise in prolactin.
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