A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Glucagon Online, Description, Chemistry, Ingredients - Glucagon
Glucagon Online, Description, Chemistry, Ingredients - Glucagon
GLUCAGON
FOR INJECTION
(rDNA ORIGIN)
DESCRIPTION
Glucagon for Injection (rDNA origin)
is a polypeptide hormone
identical to human
glucagon that increases
blood glucose and relaxes
smooth muscle of the
gastrointestinal
tract. Glucagon is synthesized in a special non- pathogenic laboratory
strain of
Escherichia coli bacteria
that has been genetically altered by the addition
of the gene for glucagon.
Glucagon is a single- chain
polypeptide that
contains 29 amino acid
residues and has a molecular weight
of 3,483.
The empirical
formula is C153H225N43O49S.
The primary sequence
of glucagon is shown
below.
Crystalline glucagon
is a white to off- white
powder. It is relatively insoluble
in water but is soluble
at a pH of less than 3 or
more than 9.5.
Glucagon is available for use intravenously,
intramuscularly, or subcutaneously in a kit that contains a vial
of sterile glucagon and a syringe
of sterile diluent.
The vial contains 1 mg
(1 unit) of glucagon
and 49 mg of lactose. Hydrochloric
acid may have been added
during manufacture to adjust the pH
of the glucagon.1 One International Unit of glucagon
is equivalent to
1 mg of glucagon. The diluent
syringe contains 12 mg/ mL of glycerin, water
for injection, and
hydrochloric acid.
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