A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Triavil Indications, Dosage, Storage, Stability - Perphenazine and Amitriptyline
Triavil Indications, Dosage, Storage, Stability - Perphenazine and Amitriptyline
INDICATIONS
AND USES
ETRAFON Tablets are indicated for the treatment of patients with moderate to
severe anxiety and/or agitation and depressed mood; patients with depression
in whom anxiety and/or agitation are moderate or severe; patients with anxiety
and depression associated with chronic physical disease; patients in whom depression
and anxiety cannot be clearly differentiated.
Schizophrenic patients who have associated symptoms of depression should be
considered for therapy with ETRAFON.
DOSAGE AND ADMINISTRATION
Initial Dosage
In psychoneurotic patients whose anxiety and depression warrant combined therapy,
one ETRAFON Tablet (2-25) or one ETRAFON-Forte Tablet (4-25) three or four times
a day is recommended.
In elderly patients and adolescents, a lower initial dosage may be needed.
The dosage may then be adjusted cautiously to produce an adequate response.
In more severely ill patients with schizophrenia, two ETRAFON-Forte Tablets
(4-25) three times a day are recommended as the initial dosage. If necessary,
a fourth dose may be given at bedtime. The total daily dosage should not exceed
eight tablets of any strength.
Maintenance Dosage
Depending on the condition being treated, the onset of therapeutic response
may vary from a few days to a few weeks or even longer. After a satisfactory
response is noted, dosage should be reduced to the smallest dose which is effective
for relief of the symptoms for which ETRAFON Tablets are being administered.
A useful maintenance dosage is one ETRAFON Tablet (2-25) or one ETRAFON-Forte
Tablet (4-25) two to four times a day. In some patients, maintenance dosage
is required for many months.
ETRAFON 2-10 Tablets (2-10) can be used to increase flexibility in adjusting
maintenance dosage to the lowest amount consistent with relief of symptoms.
HOW SUPPLIED
ETRAFON 2-10 Tablets (perphenazine 2 mg and amitriptyline hydrochloride 10
mg): deep yellow, sugar-coated tablets branded in blue-black with the Schering
trademark and either product identification letters ANA, or number 287; bottles
of 100 (NDC 0085-0287-04) and box of 100 for unit-dose dispensing (10 strips
of 10 tablets each) (NDC 0085-0287-08).
ETRAFON Tablets (perphenazine 2 mg and amitriptyline hydrochloride 25 mg):
pink, sugar-coated tablets branded in red with the Schering trademark and either
product identification letters ANC, or number 598; bottles of 100 (NDC 0085-0598-04)
and box of 100 for unit-dose dispensing (10 strips of 10 tablets each) (NDC
0085-0598-08).
ETRAFON-Forte Tablets (perphenazine 4 mg and amitriptyline hydrochloride 25
mg): red, sugar-coated tablets branded in blue with the Schering trademark and
either product identification letters ANE, or number 720; bottles of 100 (NDC
0085-0720-04) and box of 100 for unit-dose dispensing (10 strips of 10 tablets
each) (NDC 0085-0720-08).
Store ETRAFON 2-10, 2-25, 4-25 Tablets between 2° and 25°C (36° and 77°F).
In addition, protect unit-dose packages from excessive moisture.
* Poisindex® Toxicologic Management. Topic: Antidepressants, Tricyclic.
Micromedex Inc. Vol 85.
ETRAFON®
brand of perphenazine and
amitriptyline hydrochloride
ETRAFON 2-10 TABLETS (2-10), USP
ETRAFON TABLETS (2-25), USP
ETRAFON-FORTE TABLETS (4-25), USP
Schering Corporation
Kenilworth, NJ 07033 USA
All rights reserved.
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