A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Emcyt Side Effects, and Drug Interactions - Estramustine
Emcyt Side Effects, and Drug Interactions - Estramustine
SIDE EFFECTS
In a randomized, double-blind trial comparing therapy with EMCYT Capsules in
93 patients (11.5 to 15.9 mg/kg/day) or diethylstilbestrol (DES) in 93 patients
(3.0 mg/day), the following adverse effects were reported:
|
|
EMCYT
n=93 |
DES
n=93 |
|
CARDIOVASCULAR-RESPIRATORY
|
|
Cardiac Arrest
|
0 |
2 |
|
Cerebrovascular Accident
|
2 |
0 |
|
Myocardial Infarction
|
3 |
1 |
|
Thrombophlebitis
|
3 |
7 |
|
Pulmonary Emboli
|
2 |
5 |
|
Congestive Heart Failure
|
3 |
2 |
|
Edema
|
19 |
17 |
|
Dyspnea
|
11 |
3 |
|
Leg Cramps
|
8 |
11 |
|
Upper Respiratory Discharge
|
1 |
1 |
|
Hoarseness
|
1 |
0 |
|
GASTROINTESTINAL
|
|
Nausea
|
15 |
8 |
|
Diarrhea
|
12 |
11 |
|
Minor Gastrointestinal Upset
|
11 |
6 |
|
Anorexia
|
4 |
3 |
|
Flatulence
|
2 |
0 |
|
Vomiting
|
1 |
1 |
|
Gastrointestinal Bleeding
|
1 |
0 |
|
Burning Throat
|
1 |
0 |
|
Thirst
|
1 |
0 |
|
INTEGUMENTARY
|
|
Rash
|
1 |
4 |
|
Pruritus
|
2 |
2 |
|
Dry Skin
|
2 |
0 |
|
Pigment Changes
|
0 |
3 |
|
Easy Bruising
|
3 |
0 |
|
Flushing
|
1 |
0 |
|
Night Sweats
|
0 |
1 |
|
Fingertip Peeling Skin
|
1 |
0 |
|
Thinning Hair
|
1 |
1 |
|
BREAST CHANGES
|
|
Tenderness
|
66 |
64 |
|
Enlargement
|
|
|
|
Mild
|
60 |
54 |
|
Moderate
|
10 |
16 |
|
Marked
|
0 |
5 |
|
MISCELLANEOUS
|
|
Lethargy Alone
|
4 |
3 |
|
Depression
|
0 |
2 |
|
Emotional Lability
|
2 |
0 |
|
Insomnia
|
3 |
0 |
|
Headache
|
1 |
1 |
|
Anxiety
|
1 |
0 |
|
Chest Pain
|
1 |
1 |
|
Hot Flashes
|
0 |
1 |
|
Pain in Eyes
|
0 |
1 |
|
Tearing of Eyes
|
1 |
1 |
|
Tinnitus
|
0 |
1 |
|
LABORATORY ABNORMALITIES
|
|
Hematologic
|
|
|
|
Leukopenia
|
4 |
2 |
|
Thrombopenia
|
1 |
2 |
|
Hepatic
|
|
|
|
Bilirubin Alone
|
1 |
5 |
|
Bilirubin and LDH
|
0 |
1 |
|
Bilirubin and SGOT
|
2 |
1 |
|
Bilirubin, LDH and SGOT
|
2 |
0 |
|
LDH and/or SGOT
|
31 |
28 |
|
Miscellaneous
|
|
|
|
Hypercalcemia Transient
|
0 |
1 |
DRUG INTERACTIONS
Calcium-rich foods or drugs may impair the absorption of EMCYT.
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