Ergostat Side Effects, and Drug Interactions - Ergotamine

Ergostat Side Effects, and Drug Interactions - Ergotamine

SIDE EFFECTS

Nausea and vomiting occur in up to 10% of patients after ingestion of therapeutic doses of ergotamine. Weakness of the legs and pain in limb muscles are also frequent complaints. Numbness and tingling of the fingers and toes, precordial pain, transient changes in heart rate and localized edema and itching may also occur, particularly in patients who are sensitive to the drug.

DRUG ABUSE AND DEPENDENCE

Patients who take ergotamine for extended periods of time may become dependent upon it and require progressively increasing doses for relief of vascular headaches, and for prevention of dysphoric effects which follow withdrawal of the drug.

The effects of ERGOMAR may be potentiated by triacetyloleandomycin which inhibits the metabolism of ergotamine. The pressor effects of ERGOMAR and other vasoconstrictor drugs can combine to cause dangerous hypertension.