A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Lufyllin Side Effects, and Drug Interactions - Dyphylline
Lufyllin Side Effects, and Drug Interactions - Dyphylline
SIDE EFFECTS
Adverse reactions with the use of LUFYLLIN have been infrequent, relatively
mild, and rarely required reduction in dosage or withdrawal of therapy.
The following adverse reactions which have been reported with other xanthine
bronchodilators, and which have most often been related to excessive drug plasma
levels, should be considered as potential adverse effects when dyphylline is
administered:
Gastrointestinal: nausea, vomiting, epigastric pain, hematemesis,
diarrhea.
Central nervous system: headache, irritability, restlessness,
insomnia, hyperexcitability, agitation, muscle twitching, generalized clonic
and tonic convulsions.
Cardiovascular: palpitation, tachycardia, extrasystoles,
flushing, hypotension, circulatory failure, ventricular arrhythmias.
Respiratory: tachypnea.
Renal: albuminuria, gross and microscopic hematuria, diuresis.
Other: hyperglycemia, inappropriate ADH syndrome.
DRUG INTERACTIONS
Synergism between xanthine bronchodilators
(e.g., theophylline), ephedrine, and other sympathomimetic bronchodilators has
been reported. This should be considered whenever these agents are prescribed
concomitantly.
Concurrent administration of dyphylline and probenecid, which competes for
tubular secretion, has been shown to increase the plasma half-life of dyphylline
(see Clinical PHARMACOLOGY ).
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