A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Anzemet Online, Description, Chemistry, Ingredients - Dolasetron
Anzemet Online, Description, Chemistry, Ingredients - Dolasetron
DESCRIPTION
ANZEMET (dolasetron mesylate) is an antinauseant and antiemetic
agent. Chemically, dolasetron mesylate is ( 2 a,
6 a, 8 a,
9 a b)-octahydro-3-oxo-2,
6-methano-2H-quinolizin-8-yl-lH- indole-3-carboxylate
monomethanesulfonate, monohydrate. It is a highly specific and selective
serotonin subtype
3
(5-HT3) receptor
antagonist both in
vitro and in vivo. The empirical
formula is C19H20N2O3
• CH3SO3H
• H2O, with a molecular weight of
438.50. Approximately 74% of dolasetron mesylate monohydrate is
dolasetron base.
Dolasetron mesylate monohydrate is a white
to off-white powder that
is freely soluble in
water and propylene glycol,
slightly soluble in
ethanol, and slightly soluble
in normal saline.
Each ANZEMET Tablet for oral
administration
contains dolasetron mesylate (as the monohydrate) and also contains
the inactive ingredients: carnauba wax, croscarmellose sodium,
hydroxypropyl methylcellulose, lactose, magnesium stearate, polyethylene
glycol, polysorbate 80, pregelatinized starch,
synthetic red iron oxide,
titanium dioxide, and
white wax. The tablets
are printed with black
ink, which contains lecithin, pharmaceutical
glaze, propylene glycol, and synthetic
black iron
oxide.
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