A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Tikosyn Online, Description, Chemistry, Ingredients - Dofetilide
Tikosyn Online, Description, Chemistry, Ingredients - Dofetilide
DESCRIPTION
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To minimize the risk of induced arrhythmia, patients initiated or re-initiated
on TIKOSYN should be placed for a minimum of 3 days in a facility that
can provide calculations of creatinine clearance, continuous electrocardiographic
monitoring, and cardiac resuscitation. For detailed instructions regarding
dose selection, see DOSAGE AND ADMINISTRATION . TIKOSYN is available
only to hospitals and prescribers who have received appropriate TIKOSYN
dosing and treatment initiation education, see DOSAGE AND ADMINISTRATION
.
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TIKOSYN (dofetilide) is an antiarrhythmic drug with Class III (cardiac action
potential duration prolonging) properties. Its empirical formula is C 19
H 27 N 3 O 5 S 2 and it has
a molecular weight of 441.6.
The chemical name for dofetilide is N -[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-
methanesulfonamide.
Dofetilide is a white to off-white powder. It is very slightly soluble in water
and propan-2-ol and is soluble in 0.1M aqueous sodium hydroxide, acetone and
aqueous 0.1M hydrochloric acid.
TIKOSYN capsules contain the following inactive ingredients: microcrystalline
cellulose, corn starch, colloidal silicon dioxide and magnesium stearate. TIKOSYN
is supplied for oral administration in three dosage strengths: 125 mcg (0.125
mg) orange and white capsules, 250 mcg (0.25 mg) peach capsules, and 500 mcg
(0.5 mg) peach and white capsules.
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