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Persantine Side Effects, and Drug Interactions - Dipyridamole

SIDE EFFECTS

Adverse reactions at therapeutic doses are usually minimal and transient. On long-term use of dipyridamole initial side effects usually disappear. The following reactions were reported in two heart valve replacement trials comparing dipyridamole and warfarin therapy to either warfarin alone or warfarin and placebo:

	Dipyndamole/ Warfarin (N= 147)	Placebo/ Warfarin (N= 170)
Dizziness	13.6%	8.2%
Abdominal distress	6.1%	3.5%
Headache	2.3%	0.0%
Rash	2.3%	1.1%

Other reactions from uncontrolled studies include diarrhea, vomiting, flushing and pruritis. In addition, angina pectoris has been reported rarely. On those uncommon occasions when adverse reactions have been persistent or intolerable, they have ceased on withdrawal of the medication. When dipyridamole was administered concomitantly with warfarin, bleeding was no greater in frequency or severity than that observed when warfarin was administered alone.

DRUG INTERACTIONS

No infromation provided.

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