A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cervidil Online, Description, Chemistry, Ingredients - Dinoprostone
Cervidil Online, Description, Chemistry, Ingredients - Dinoprostone
DESCRIPTION
Dinoprostone vaginal insert is a thin, flat, polymeric slab which is rectangular
in shape with rounded corners contained within the pouch of a knitted polyester
retrieval system, an integral part of which is a long tape. Each slab is buff
colored, semitransparent and contains 10 mg of dinoprostone. The hydrogel insert
is contained within the pouch of an off-white knitted polyester retrieval system
designed to aid retrieval at the end of the dosing interval. The finished product
is a controlled release formulation which has been found to release dinoprostone
in vivo at a rate of approximately 0.3 mg/hr.
The chemical name for dinoprostone (commonly known as prostaglandin E 2
or PGE 2 ) is 11(alpha), 15S-dihydroxy-9-oxo-prosta-5Z, 13E-dien-1-oic
acid.
The molecular formula is C 20 H 32 O 5 and
its molecular weight is 352.5. Dinoprostone occurs as a white to off-white crystalline
powder. It has a melting point within the range of 65° to 69°C. Dinoprostone
is soluble in ethanol and in 25% ethanol in water. Each insert contains 10 mg
of dinoprostone in 241 mg of a cross-linked polyethylene oxide/urethane polymer
which is a semi-opaque, beige colored, flat rectangular slab measuring 29 mm
by 9.5 mm and 0.8 mm in thickness. The insert and its retrieval system, made
of polyester yarn, are non-toxic and when placed in a moist environment, absorb
water, swell, and release dinoprostone.
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