A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Dienestrol Side Effects, and Drug Interactions - Dienestrol
Dienestrol Side Effects, and Drug Interactions - Dienestrol
SIDE EFFECTS
(See WARNINGS regarding induction
of neoplasia, adverse effects on the fetus,
increased incidence
of gall bladder disease,
and adverse effects similar to those of oral
contraceptives, including thromboembolism.) The following additional
adverse reactions have been reported with estrogenic
therapy, including oral
contraceptives:
1. Genitourinary system.
- Increase in size of uterine
fibromyomata.
- Vaginal candidiasis.
- Breakthrough bleeding,
spotting, change in menstrual flow.
- Dysmenorrhea. Premenstrual-like syndrome.
- Amenorrhea during and after treatment.
- Change in cervical
eversion and in degree
of cervical secretion.
- Cystitis-like syndrome.
2. Breasts.
Tenderness, enlargement, secretion.
3. Gastrointestinal.
- Cholestatic jaundice.
- Nausea, vomiting.
- Abdominal cramps, bloating.
4. Skin.
- Erythema multiforme.
- Erythema nodosum.
- Hemorrhagic eruption.
- Loss of scalp hair.
- Hirsutism.
- Chloasma or melasma
which may persist when drug
is discontinued.
5. Eyes.
- Steepening of corneal curvature.
- Intolerance to contact
lenses.
6. CNS.
- Mental depression.
- Headache, migraine,
dizziness.
- Chorea.
7. Miscellaneous.
- Reduced carbohydrate
tolerance.
- Aggravation of porphyria.
- Edema.
- Changes in libido.
- Increase or decrease in weight.
DRUG INTERACTIONS
Drug/ Laboratory Test Interactions
Certain endocrine
and liver function
tests may be affected by estrogen-containing oral contraceptives.
The following similar changes may be expected with larger doses
of estrogen:
- Increased sulfobromophthalein
retention.
- Increased prothrombin
and factors VII, VIII, IX, and X; decreased antithrombin 3; increased
norepinephrine-induced platelet
aggregability.
- Increased thyroid-binding globulin
(TBG) leading to in-creased circulating total thyroid
hormone; as measured by PBI, T4 by column, or T4 by radioimmunoassay.
Free T3 resin uptake
is decreased, reflecting the elevated TBG; free T4 concentration
is unaltered.
- Impaired glucose
tolerance.
- Decreased pregnanediol
excretion.
- Reduced response
to metyrapone test.
- Reduced serum folate
concentration.
- Increased serum triglyceride
and phospholipid
concentration.
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