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Stimate Side Effects, and Drug Interactions - Desmopressin Acetate

Stimate Side Effects, and Drug Interactions - Desmopressin Acetate

SIDE EFFECTS

Infrequently, DDAVP® Injection has produced transient headache, nausea, mild abdominal cramps and vulval pain. These symptoms disappeared with reduction in dosage. Occasional facial flushing has been reported with the administration of DDAVP® Injection. Infrequently, high doses of intranasal DDAVP® have produced transient headache and nausea. Nasal congestion, rhinitis and flushing have also been reported occasionally along with mild abdominal cramps. These symptoms disappeared with reduction in dosage. Nosebleed, sore throat, cough and upper respiratory infections have also been reported.

In addition to those listed above, the following have also been reported in clinical trials with Stimate

Nasal Spray: Somnolence, dizziness, itchy or light-sensitive eyes, insomnia, chills, warm feeling, pain, chest pain, palpitations, tachycardia, dyspepsia, edema, vomiting, agitation and balanitis.1-4

DDAVP® Injection (desmopressin acetate) has infrequently produced changes in blood pressure causing either a slight elevation or a transient fall and a compensatory increase in heart rate. Severe allergic reactions including anaphylaxis have been reported rarely with DDAVP® Injection.

See WARNINGS for the possibility of water intoxication, hyponatremia and coma.11

DRUG INTERACTIONS

Although the pressor activity of desmopressin acetate is very low, its use with other pressor agents should be done only with careful patient monitoring.

DDAVP® Injection has been used with epsilon aminocaproic acid without adverse effects.

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