Depo Provera Side Effects, and Drug Interactions - Medroxyprogesterone

Depo Provera Side Effects, and Drug Interactions - Medroxyprogesterone

SIDE EFFECTS

In the largest clinical trial with DEPO-PROVERA Contraceptive Injection, over 3,900 women, who were treated for up to 7 years, reported the following adverse reactions, which may or may not be related to the use of DEPO-PROVERA Contraceptive Injection.

The following adverse reactions were reported by more than 5% of subjects:

Menstrual irregularities

  (bleeding or amenorrhea, or both)

Weight changes

Headache

Nervousness

Abdominal pain or discomfort

Dizziness

Asthenia (weakness or fatigue)

Adverse reactions reported by 1% to 5% of subjects using DEPO-PROVERA Contraceptive Injection were:

Decreased libido or anorgasmia

Backache

Leg cramps

Depression

Nausea

Insomnia

Leukorrhea

Acne

Vaginitis

Pelvic pain

Breast pain

No hair growth or alopecia

Bloating

Rash

Edema

Hot flashes

Arthralgia

Events reported by fewer than 1% of subjects included: galactorrhea, melasma, chloasma, convulsions, changes in appetite, gastrointestinal disturbances, jaundice, genitourinary infections, vaginal cysts, dyspareunia, paresthesia, chest pain, pulmonary embolus, allergic reactions, anemia, drowsiness, syncope, dyspnea and asthma, tachycardia, fever, excessive sweating and body odor, dry skin, chills, increased libido, excessive thirst, hoarseness, pain at injection site, blood dyscrasia, rectal bleeding, changes in breast size, breast lumps or nipple bleeding, axillary swelling, breast cancer, prevention of lactation, sensation of pregnancy, lack of return to fertility, paralysis, facial palsy, scleroderma, osteoporosis, uterine hyperplasia, cervical cancer, varicose veins, dysmenorrhea, hirsutism, unexpected pregnancy, thrombophlebitis, deep vein thrombosis.

In addition, voluntary reports have been received of anaphylaxis and anaphylactoid reaction with use of DEPO-PROVERA Contraceptive Injection.

Aminoglutethimide administered concomitantly with the DEPO-PROVERA Contraceptive Injection may significantly depress the serum concentrations of medroxyprogesterone acetate. ¹² Users of DEPO-PROVERA Contraceptive Injection should be warned of the possibility of decreased efficacy with the use of this or any related drugs.