A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cerubidine Online, Description, Chemistry, Ingredients - Daunorubicin
Cerubidine Online, Description, Chemistry, Ingredients - Daunorubicin
DESCRIPTION
WARNING
- Cerubidine must be given into a rapidly flowing intravenous infusion.
It must never be given by the intramuscular or subcutaneous route.
Severe local tissue necrosis will occur if there is extravasation during
administration.
- Myocardial toxicity manifested in its most severe form by potentially
fatal congestive heart failure may occur either during therapy or months
to years after termination of therapy. The incidence of myocardial toxicity
increases after a total cumulative dose exceeding 400 to 550 mg/m 2
in adults, 300 mg/m 2 in children more than 2 years
of age, or 10 mg/kg in children less than 2 years of age.
- Severe myelosuppression occurs when used in therapeutic doses; this
may lead to infection or hemorrhage.
- It is recommended that Cerubidine be administered only by physicians
who are experienced in leukemia chemotherapy and in facilities with
laboratory and supportive resources adequate to monitor drug tolerance
and protect and maintain a patient compromised by drug toxicity. The
physician and institution must be capable of responding rapidly and
completely to severe hemorrhagic conditions and/or overwhelming infection.
- Dosage should be reduced in patients with impaired hepatic or renal
function.
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Cerubidine (daunorubicin hydrochloride) is the hydrochloride salt of an anthracycline
cytotoxic antibiotic produced by a strain of Streptomyces coeruleorubidus.
It is provided as a sterile reddish lyophilized powder in vials for intravenous
administration only. Each vial contains 21.4 mg daunorubicin hydrochloride,
(equivalent to 20 mg of daunorubicin), and 100 mg mannitol. It is soluble in
water when adequately agitated and produces a reddish solution. It has the following
structural formula which may be described with the chemical name of (1 S
,3 S )-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl
3-amino-2,3,6-trideoxy-(alpha)-L- lyxo -hexopyranoside hydrochloride.
Its molecular formula is C 27 H 29 NO 10 ·HCl
with a molecular weight of 563.99. It is a hygroscopic crystalline powder. The
pH of a 5 mg/mL aqueous solution is 4.5 to 6.5. Its structual formula is:
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