A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Dtic-Dome Side Effects, and Drug Interactions - dacarbazine
Dtic-Dome Side Effects, and Drug Interactions - dacarbazine
SIDE EFFECTS
Symptoms of anorexia, nausea, and vomiting are the most frequently noted of
all toxic reactions. Over 90% of patients are affected with the initial few
doses. The vomiting lasts 1-12 hours and is incompletely and unpredictably palliated
with phenobarbital and/or prochlorperazine. Rarely, intractable nausea and vomiting
have necessitated discontinuance of therapy with DTIC-Dome. Rarely, DTIC-Dome
has caused diarrhea. Some helpful suggestions include restricting the patient's
oral intake of food for 4-6 hours prior to treatment. The rapid toleration of
these symptoms suggests that a central nervous system mechanism may be involved,
and usually these symptoms subside after the first 1 or 2 days.
There are a number of minor toxicities that are infrequently noted. Patients
have experienced an influenza-like syndrome of fever to 39°C, myalgias and malaise.
These symptoms occur usually after large single doses, may last for several
days, and they may occur with successive treatments.
Alopecia has been noted as has facial flushing and facial paresthesia. There
have been few reports of significant liver or renal function test abnormalities
in man. However, these abnormalities have been observed more frequently in animal
studies.
Erythematous and urticarial rashes have been observed infrequently after administration
of DTIC-Dome. Rarely, photosensitivity reactions may occur.
DRUG INTERACTIONS
No Information Provided.
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