A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Intal Side Effects, and Drug Interactions - Cromolyn
Intal Side Effects, and Drug Interactions - Cromolyn
SIDE EFFECTS
In controlled clinical
studies of Intal Inhaler, the most frequently reported adverse reactions
attributed to cromolyn sodium
treatment were:
- Throat irritation
or dryness
- Bad taste
- Cough
- Wheeze
- Nausea
The most frequently reported adverse reactions attributed to other
forms of cromolyn sodium
(on the basis of reoccurrence
following readministration) involve the respiratory
tract and are: bronchospasm
[sometimes severe, associated with a precipitous fall
in- pulmonary function
(FEV1)], cough, laryngeal
edema (rare), nasal
congestion (sometimes
severe), pharyngeal irritation, and wheezing.
Adverse reactions which occur infrequently and are associated with
administration of the drug
are: anaphylaxis,
angioedema, dizziness,
dysuria and urinary
frequency, joint swelling
and pain, lacrimation,
nausea and headache,
rash, swollen parotid
gland, urticaria,
pulmonary infiltrates
with eosinophilia, substernal burning, and myopathy.
The following adverse reactions have been reported as rare events
and it is unclear whether they are attributable to the drug: anemia,
exfoliative dermatitis, hemoptysis,
hoarseness, myalgia,
nephrosis, periarteritic vasculitis, pericarditis, peripheral
neuritis, photodermatitis,
sneezing, drowsiness, nasal itching, nasal
bleeding, nasal
burning, serum sickness,
stomachache, polymyositis, vertigo, and liver
disease.
DRUG INTERACTIONS
Drug Interaction During Pregnancy: Cromolyn sodium
and isoproterenol were studied following subcutaneous
injections in pregnant mice. Cromolyn sodium
alone in doses up to 540 mg/kg/day (approximately 340 times the
maximum recommended
daily inhalation
dose in adults on a mg/m2
basis) did not cause significant
increases in resorptions or major malformations. Isoproterenol alone
at a dose of 2.7 mg/kg/day
(approximately 7 times the maximum
recommended daily inhalation
dose in adults on a mg/m2
basis) increased both resorptions and malformations. The addition
of 540 mg/kg/day of cromolyn sodium
(approximately 340 times the maximum
recommended daily inhalation
dose in adults on a mg/m2
basis) to 2.7 mg/kg/day of isoproterenol (approximately 7 times
the maximum recommended daily inhalation
dose in adults on a mg/m2
basis) appears to have increased the incidence
of both resorptions and malformations.
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