A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Combivent Online, Description, Chemistry, Ingredients - Ipratropium and Albuterol
Combivent Online, Description, Chemistry, Ingredients - Ipratropium and Albuterol
DESCRIPTION
Combivent® (ipratropium bromide
and albuterol sulfate)
Combivent® Inhalation Aerosol is a combination of ipratropium
bromide and albuterol sulfate. Ipratropium bromide
is an anticholinergic
bronchodiiator chemically described as 8- azoniabicyclo[ 3.2.1]
octane, 3-(3-hydroxy-1oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-,
bromide, monohydrate (endo, syn)-,(+): a synthetic
quaternary ammonium
compound chemically related to afropine. Ipratropium bromide
is a white to off-white crystalline
substance. freely soluble
in water and lower alcohols
but insoluble in lipophilic
solvents such as ether,
chloroform and fluorocarbons.
Albuterol sulfate, chemically known as (13-benzenedimethanol, a’-
((1,1-dimethylethyl)amino] methyl]- 4- hydroxy, sulfate
(2:1)(salt), (+)- is a relatively selective beta2-adrenergic bronchodilator.
Albuterol is the official
generic name in the
United States. The World Health Organization recommended name for
the drug is salbutamol.
Albuterol sulfate
is a white to off-white
crystalline powder soluble
in water and slightly
soluble in ethanol.
Combivent® Inhalation Aerosol contains a microcrystalline
suspension of ipratropium bromide
and albuterol sulfate
in a pressurized metered-dose aerosol unit
for oral inhalation
administration. The 200 inhalation
unit has a net weight
of 14.7 grams. Each actuation meters 21 mcg
of ipratropium bromide and 120 mcg
of albuterol sulfate
from the valve and delivers
18 mcg of ipratropium bromide
and 103 mcg of albuterol
sulfate (equivalent
to 90 mcg albuterol base)
from the mouthpiece. The excipients are dichlorodifluoromethane,
dichlorotetrafluoroethane, and trichloromonofluoromethane as propellants
and soya lecithin.
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