Coly-Mycin Side Effects, and Drug Interactions - Sterile Colistimethate Sodium

Coly-Mycin Side Effects, and Drug Interactions - Sterile Colistimethate Sodium SIDE EFFECTS

The following adverse reactions have been reported:

Gastrointestinal:   gastrointestinal upset

Nervous System:   tingling of extremities and tongue, slurred speech, dizziness, vertigo and paresthesia

Integumentary:   generalized itching, urticaria and rash

Body as a Whole:   fever

Laboratory Deviations:   increased blood urea nitrogen (BUN), elevated creatinine and decreased creatinine clearance

Respiratory System:   respiratory distress and apnea

Renal System:   nephrotoxicity and decreased urine output

DRUG INTERACTIONS

Certain other antibiotics (aminoglycosides and polymyxin) have also been reported to interfere with the nerve transmission at the neuromuscular junction. Based on this reported activity, they should not be given concomitantly with Coly-Mycin M Parenteral except with the greatest caution.

Curariform muscle relaxants (eg, tubocurarine) and other drugs, including ether, succinylcholine, gallamine, decamethonium and sodium citrate, potentiate the neuromuscular blocking effect and should be used with extreme caution in patients being treated with Coly-Mycin M Parenteral.

Sodium cephalothin may enhance the nephrotoxicity of Coly-Mycin M Parenteral. The concomitant use of sodium cephalothin and Coly-Mycin M Parenteral should be avoided.