A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Colchicine Warnings, Precautions, Pregnancy, Nursing, Abuse - Colchicine
Colchicine Warnings, Precautions, Pregnancy, Nursing, Abuse - Colchicine
WARNINGS
Colchicine arrests cell
division in animals and plants. It has adversely affected spermatogenesis
in humans and in some animal
species under certain
conditions.
PRECAUTIONS
General
Colchicine should be administered with caution to aged
or debilitated patients, and to those with early manifestations
of gastrointestinal,
renal, hepatic, cardiac,
or hematological disorders. (see CONTRAINDICATIONS).
If nausea, vomiting,
or diarrhea occurs,
the drug should be discontinued,
Laboratory Tests
In patients receiving longterm therapy,
periodic blood
counts should be done.
Drug Interactions
Colchicine is inhibited by acidifying agents. The action
of colchicine is potentiated by alkalinizing agents.
Colchicine may increase sensitivity
to the CNS depressants.
Response to sympathomimetic agentsmay be enhanced by colchicine.
Laboratory Test Interactions
Colchicine therapy
may cause elevated alkaline
phosphatase and
SGOT values.
Decreased thrombocyte
values may be obtained during colchicine
therapy.
Colchicine may cause
false positive results
when testing urine for
RBC or hemoglobin.
Carcinogenesis
Data in the literature does not indicate colchicine
as a carcinogenic agent.
Fertility
See WARNINGS
section
for information on impairment of fertility.
Pregnancy
Pregnancy Category C. Colchicine has been shown to
be teratogenic in mice when given doses of 1.25 and 1.5 mg/kg and
in hamsters when given 10 mg/kg. There are no
adequate and well-controlled studies in pregnant
women. Colchicine should be used during pregnancy
only if the potential benefit
justifies the potential
risk to the fetus.
Nursing Mothers
It is not known whether this drug
is excreted in human milk.
Because many drugs are excreted in human
milk, caution should be exercised when colchicine is administered
to a nursing woman.
top
