A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Combipres Online, Description, Chemistry, Ingredients - Clonidine
Combipres Online, Description, Chemistry, Ingredients - Clonidine
DESCRIPTION
CLORPRES™ is a combination of clonidine hydrochloride (a centrally acting antihypertensive
agent) and chlorthalidone (a diuretic). CLORPRES™ is available as tablets for
oral administration in three dosage strengths: 0.1 mg/15 mg, 0.2
mg/15 mg and 0.3 mg/15 mg of clonidine hydrochloride/chlorthalidone, respectively.
The inactive ingredients are ammonium chloride, colloidal silicon dioxide,
croscarmellose sodium (Type A), magnesium stearate, microcrystalline cellulose,
sodium lauryl sulfate, D&C yellow #10.
Clonidine Hydrochloride: Clonidine hydrochloride is an imidazoline
derivative and exists as a mesomeric compound. The chemical name is 2-[(2,6-dichlorophenyl)imino]imidazoline
monohydrochloride.
Clonidine hydrochloride is an odorless, bitter, white crystalline substance
soluble in water and alcohol.
Chlorthalidone: Chlorthalidone is a monosulfamyl diuretic
that differs chemically from thiazide diuretics in that a double ring system
is incorporated in its structure. It is 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)
benzenesulfonamide.
Chlorthalidone is practically insoluble in water, in ether and in chloroform;
soluble in methanol; slightly soluble in alcohol.
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