A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cleocin Side Effects, and Drug Interactions - Clindamycin
Cleocin Side Effects, and Drug Interactions - Clindamycin
SIDE EFFECTS
The following reactions have been reported with the use of clindamycin.
Gastrointestinal: Abdominal pain, pseudomembranous colitis,
esophagitis, nausea, vomiting and diarrhea (see WARNING box). The onset
of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNING).
Hypersensitivity Reactions: Generalized mild to moderate
morbilliform-like (maculopapular) skin
rashes are the most frequently reported adverse reactions. Vesiculobullous
rashes, as well as urticaria,
have been observed during drug
therapy. Rare instances of erythema
muttiforme, some resembling Stevens-Johnson syndrome,
and a few cases of anaphylactoid reactions have also been reported.
Skin and Mucous Membranes: Pruritus, vaginitis,
and rare instances of exfoliative dermatitis
have been reported. (See Hypersensitivity Reactions
above)
Liver: Jaundice and abnormalities in liver
function tests have
been observed during clindamycin therapy.
Renal: Although no
direct relationship of clindamycin to renal
damage has been established, renal
dysfunction as evidenced
by azotemia, oliguria,
and/or proteinuria
has been observed in rare instances.
Hematopoietic: Transient neutropenia
(leukopenia) and eosinophilia have been reported. Reports of agranulocytosis
and thrombocytopenia have been made. No
direct etiologic relationship to concurrent clindamycin therapy
could be made in any of the foregoing.
Musculoskeletal: Rare instances of polyarthritis
have been reported.
DRUG INTERACTIONS
Clindamycin has been shown to have neuromuscular blocking properties that may
enhance the action of other neuromuscular blocking agents. Therefore, it should be
used with caution in patients receiving such agents. Antagonism has been demonstrated
between clindamycin and erythromycin in vitro. Because of possible clinical significance,
these two drugs should not be administered concurrently.
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