A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cipro Online, Description, Chemistry, Ingredients - Ciprofloxacin
Cipro Online, Description, Chemistry, Ingredients - Ciprofloxacin
DESCRIPTION
CIPRO® I.V. (ciprofloxacin) is a synthetic broad-spectrum antimicrobial agent
for intravenous (I.V.) administration. Ciprofloxacin, a fluoroquinolone, is
1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl) -3- quinolinecarboxylic
acid. Its empirical formula is C 17 H 18 FN 3 O
3.
Ciprofloxacin is a faint to light yellow crystalline powder with a molecular
weight of 331.4. It is soluble in dilute (0.1N) hydrochloric acid and is practically
insoluble in water and ethanol. Ciprofloxacin differs from other quinolones
in that it has a fluorine atom at the 6-position, a piperazine moiety at the
7-position, and a cyclopropyl ring at the 1-position. CIPRO® I.V. solutions
are available as sterile 1.0% aqueous concentrates, which are intended for dilution
prior to administration, and as 0.2% ready-for-use infusion solutions in 5%
Dextrose Injection. All formulas contain lactic acid as a solubilizing agent
and hydrochloric acid for pH adjustment. The pH range for the 1.0% aqueous concentrates
in vials is 3.3 to 3.9. The pH range for the 0.2% ready-for-use infusion solutions
is 3.5 to 4.6.
The plastic container is fabricated from a specially formulated polyvinyl chloride.
Solutions in contact with the plastic container can leach out certain of its
chemical components in very small amounts within the expiration period, e.g.,
di(2-ethylhexyl) phthalate (DEHP), up to 5 parts per million. The suitability
of the plastic has been confirmed in tests in animals according to USP biological
tests for plastic containers as well as by tissue culture toxicity studies.
top
