Cholera Vaccine Side Effects, and Drug Interactions - Cholera Vaccine

Cholera Vaccine Side Effects, and Drug Interactions - Cholera Vaccine

SIDE EFFECTS

Local reactions manifested by erythema, induration, pain, and tenderness at the site of injection occur in most recipients, and such local reactions may persist for a few days.

Recipients frequently develop malaise, headache, and mild-to-moderate temperature elevations which may persist for 1 to 2 days. ^1,4

Some data suggest that administration of cholera and yellow fever vaccines within three weeks of each other may result in decreased levels of antibody response to both vaccines as compared with administration at longer intervals. However, there is no evidence that protection to either disease is diminished following simultaneous administration. ¹ It is currently recommended that, when feasible, cholera and yellow fever vaccines should be administered at a minimal interval of three weeks, unless time constraints preclude this. If the vaccines cannot be administered at least three weeks apart, they should be given simultaneously. ²