A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Parafon Forte Warnings, Precautions, Pregnancy, Nursing, Abuse - Chlorzoxazone
Parafon Forte Warnings, Precautions, Pregnancy, Nursing, Abuse - Chlorzoxazone
WARNINGS
Serious (including fatal) hepatocellular
toxicity has been reported
rarely in patients receiving chlorzoxazone. The mechanism
is unknown but appears to be idiosyncratic and unpredictable. Factors
predisposing patients
to this rare event are not known. Patients should be instructed
to report early signs and/or symptoms of heptatoxicity such
as fever, rash,
anorexia, nausea, vomiting,
fatigue, right
upper quadrant pain,
dark urine, or jaundice.
Chlorzoxazone should be discontinued immediately and a physician
consulted if any of these signs or symptoms develop. Chlorzoxazone
use should also be discontinued if a patient
develps abnormal liver
enymes (e.g. AST, ALT, alkaline phosphatase, and bilirubin).
The concomitant
use of alcohol or other
central nervous
system depressants may
have an additive effect.
Usage in Pregnancy: The safe use of PARAFON FORTE
DSC chlorzoxazone has not been established with respect to the possible
adverse effects upon fetal
development. Therefore, it should be used in women of childbearing
potential only when,
in the judgment of
the physician, the
potential benefits outweigh the possible risks.
PRECAUTIONS
PARAFON FORTE DSC chlorzoxazone
should be used with caution in patients with known allergies or
with a history of allergic
reactions to drugs. If a sensitivity
reaction occurs such
as urticaria, redness,
or itching of the skin,
the drug should be stopped.
If any symptoms suggestive
of liver dysfunction
are observed, the drug should be discontinued.
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