Chloroptic Pharmacology, Pharmacokinetics, Studies, Metabolism - Chloramphenicol

Chloroptic Pharmacology, Pharmacokinetics, Studies, Metabolism - Chloramphenicol

CLINICAL PHARMACOLOGY

Chloramphenicol is a broad-spectrum antibiotic originally isolated from Streptomyces venezuelae. It is primarily bacteriostatic and acts by inhibition of protein synthesis by interfering with the transfer of activated amino acids from soluble RNA to ribosomes.

Chloramphenicol has been shown to be active against the following organisms:

Staphylococcus aureus

streptococci, including Streptococcus pneumoniae

Aerobic gram-negative microorganisms:

Enterobacter sp.

Escherichia coli

Haemophilus influenzae

Klebsiella sp.

Moraxella lucunata (Morax-Axenfeld bacillus)

Nesseria sp.

This product does not provide adequate coverage against Pseudomonas aeruginosa or Serratia marcescens.

Bacteriological studies should be performed to determine the causative organisms and their susceptibilities to chloramphenicol.