A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cetrotide Online, Description, Chemistry, Ingredients - Cetrorelix
Cetrotide Online, Description, Chemistry, Ingredients - Cetrorelix
DESCRIPTION
Cetrotide® (cetrorelix acetate for injection)
is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic
activity. Cetrorelix acetate is an analog of native GnRH with substitutions
of amino acids at positions 1, 2, 3, 6, and 10. The molecular formula is Acetyl-D-3-(2´-naphtyl)-alanine- D-4-chlorophenylalanine-D-3-(3´-pyridyl)- alanine-L-serine-L-tyrosine-D-citruline-L- leucine-L-arginine-L-proline-D- alanine-amide,
and the molecular weight is 1431.06, calculated as the anhydrous free base.
Cetrorelix acetate
(Ac-D-Nal1-D-Cpa2-D-Pal3-Ser4-Tyr5-D-Cit6-Leu7-Arg8-Pro9-D
-Ala10-NH2)
Cetrotide® (cetrorelix acetate for injection)
0.25 mg or 3 mg is a sterile lyophilized powder intended for subcutaneous injection
after reconstitution with Sterile Water for Injection, USP (pH 5-8), that comes
supplied in either a 1.0 mL (for 0.25 mg vial) or 3.0 mL (for 3 mg vial) pre-filled
syringe. Each vial of Cetrotide® 0.25 mg (multiple dose regimen)
contains 0.26-0.27 mg cetrorelix acetate, equivalent to 0.25 mg cetrorelix,
and 54.80 mg mannitol. Each vial of Cetrotide® 3 mg (single dose
regimen) contains 3.12-3.24 mg cetrorelix acetate, equivalent to 3 mg cetrorelix,
and 164.40 mg mannitol.
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