A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Versenate Side Effects, and Drug Interactions - EDTA - Calcium Disodium Versenate
Versenate Side Effects, and Drug Interactions - EDTA - Calcium Disodium Versenate
SIDE EFFECTS
The following adverse effects have been associated with the use of edetate
calcium disodium:
Body as a Whole: pain at intramuscular injection site, fever,
chills, malaise, fatigue, myalgia, arthralgia.
Cardiovascular: hypotension, cardiac rhythm irregularities.
Renal: acute necrosis of proximal tubules (which may result
in fatal nephrosis), infrequent changes in distal tubules and glomeruli.
Urinary: glycosuria, proteinuria, microscopic hematuria
and large epithelial cells in urinary sediment.
Nervous System: tremors, headache, numbness, tingling.
Gastrointestinal: cheilosis, nausea, vomiting, anorexia,
excessive thirst.
Hepatic: mild increases in SGOT and SGPT are common, and
return to normal within 48 hours after cessation of therapy.
Immunogenic: histamine-like reactions (sneezing, nasal congestion,
lacrimation), rash.
Hematopoietic: transient bone marrow depression, anemia,
Metabolic: zinc deficiency, hypercalcemia.
DRUG INTERACTIONS
There is no known drug interference with
standard clinical laboratory tests. Steroids enhance the renal toxicity of edetate
calcium disodium in animals. 7 Edetate calcium disodium interferes
with the action of zinc insulin preparations by chelating the zinc. 7
Carcinogenesis, Mutagenesis, Impairment of Fertility: Long term animal
studies have not been conducted with edetate calcium disodium to evaluate its
carcinogenic potential, mutagenic potential or its effect on fertility.
Pregnancy: Category B: One reproduction study was performed
in rats at doses up to 13 times the human dose and revealed no evidence of impaired
fertility or harm to the fetus due to Calcium Disodium Versenate. 10 Another
reproduction study performed in rats at doses up to about 25 to 40 times the
human dose revealed evidence of fetal malformations due to Calcium Disodium
Versenate, which were prevented by simultaneous supplementation of dietary zinc.
11 There are, however, no adequate and well-controlled studies in
pregnant women. Because animal reproduction studies are not always predictive
of human response, this drug should be used during pregnancy only if clearly
needed.
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