A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Celestone Online, Description, Chemistry, Ingredients - Betamethasone
Celestone Online, Description, Chemistry, Ingredients - Betamethasone
DESCRIPTION
Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic,
that are readily absorbed from the gastrointestinal tract. A derivative of prednisolone,
CELESTONE (betamethasone) has a 16(beta)-methyl group that enhances the anti-inflammatory
action of the molecule and reduces the sodium- and water-retaining properties
of the fluorine atom bound at carbon 9.
The formula for betamethasone is C 22 H 29 FO 5
and has a molecular weight of 392.47. Chemically, it is 9-fluoro- 11(beta),17,21-trihydroxy-16(beta)-methylpregna-1,4-diene-3,20-dione.
Betamethasone is a white to practically white, odorless, crystalline powder.
It melts at about 240°C with some decomposition. Betamethasone is sparingly
soluble in acetone, alcohol, dioxane, and methanol; very slightly soluble in
chloroform and ether; and is insoluble in water.
CELESTONE Syrup contains 0.6 mg betamethasone, USP, in each 5 mL.
The inactive ingredients for celestone Syrup include: alcohol, USP; cellulose
powdered, NF; citric acid, USP anhydrous; FD&C Red No. 40; FD&C Yellow
No. 6; Flavor Cherry Artificial 13506457 IFF; Flavor Orange Natural Terpeneless
73502530 IFF; propylene glycol, USP; sodium benzoate, NF; sodium chloride, USP;
sorbitol solution, USP; sugar granulated; and water purified, USP.
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