Cogentin Pharmacology, Pharmacokinetics, Studies, Metabolism - Benztropine

Cogentin Pharmacology, Pharmacokinetics, Studies, Metabolism - Benztropine

CLINICAL PHARMACOLOGY

Benztropine possesses both anticholinergic and antihistaminic effects, although only the former have been established as therapeutically significant in the management of parkinsonism. In the isolated guinea pig ileum, the anticholinergic activity of this drug is about equal to that of atropine; however, when administered orally to unanesthetized cats, it is only about half as active as atropine In laboratory animals, its antihistaminic activity and duration of action approach those of pyrilamine maleate. INDICATIONS AND USAGE : For use as an adjunct in the therapy of all forms of parkinsonism. Useful also in the control of extrapyramidal disorders (except tardive dyskinesia - see PRECAUTIONS) due to neuroleptic drugs (e.g. phenothiazines).