A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Autoplex-T Side Effects, and Drug Interactions - Anti-Inhibitor Coagulant Complex, Heat Treated
Autoplex-T Side Effects, and Drug Interactions - Anti-Inhibitor Coagulant Complex, Heat Treated
SIDE EFFECTS
As with other plasma preparations, reactions manifested by fever, chills or
indications of protein sensitivity may be observed with the administration of
Anti-Inhibitor Coagulant Complex, Heat Treated, Autoplex® T. Signs and/or symptoms
of high prekallikrein activity, such as changes in blood pressure or pulse rate
may also be observed. It is advisable that appropriate medications be available
for the treatment of acute allergic reactions or acute vasoactive reactions,
should they occur.
A rate of infusion that is too rapid may cause headache, flushing, and changes
in pulse rate and blood pressure. In such instances, stopping the infusion allows
the symptoms to disappear promptly. With all but the most reactive individuals,
infusion may be resumed at a slower rate.
DRUG INTERACTIONS
Since only limited data are available on the administration of highly activated
prothrombin complex products together with antifibrinolytic agents such as epsilon-aminocaproic
acid (EACA) or tranexamic acid, 6 the concomitant use of Anti-Inhibitor
Coagulant Complex, Heat Treated, Autoplex® T, with such agents is not recommended.
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