Trasylol Overdose, Contraindications and Information - Aprotinin

Trasylol Overdose, Contraindications and Information - Aprotinin

OVERDOSE

The maximum amount of Trasylol that can be safely administered in single or multiple doses has not been determined. Doses up to 17.5 million KIU have been administered within a 24 hour period without any apparent toxicity. There is one poorly documented case, however, of a patient who received a large, but not well determined, amount of Trasylol (in excess of 15 million KIU) in 24 hours. The patient who had pre existing liver dysfunction, developed hepatic and renal failure postoperatively and died. Autopsy showed hepatic necrosis and extensive renal tubular and glomerular necrosis. The relationship of these findings to Trasylol therapy is unclear.

CONTRAINDICATIONS

Hypersensitivity to aprotinin.