Prolastin Side Effects, and Drug Interactions - Alpha 1-Proteinase Inhibitor

Prolastin Side Effects, and Drug Interactions - Alpha 1-Proteinase Inhibitor

SIDE EFFECTS

Therapeutic administration of Prolastin, 60 mg/kg weekly, has been demonstrated to be well tolerated. In clinical studies, six reactions were observed with 517 infusions of Prolastin, or 1.16%. None of the reactions were severe.¹⁸ The adverse reactions reported included delayed fever (maximum temperature rise was 38.9°C, resolving spontaneously over 24 hours) occurring up to 12 hours following treatment (0.77%), light-headedness (0.19%) and dizziness (0.19%).¹⁸ Mild transient leukocytosis and dilutional anemia several hours after infusion have also been noted. ¹⁸ Since market entry, occasional reports of other flu-like symptoms, allergic-like reactions, chills, dyspnea, rash, tachycardia, and, rarely, hypotension have also been received.

DRUG INTERACTIONS

No information provided.