Thrombate Side Effects, and Drug Interactions - Antithrombin

Thrombate Side Effects, and Drug Interactions - Antithrombin

SIDE EFFECTS

In clinical studies involving THROMBATE III, adverse reactions were reported in association with 17 of the 340 infusions during the clinical studies. Included were dizziness (7), Chest tightness (3), nausea (3), foul taste in mouth (3), chills (2), cramps (2), shortness of breath (1), chest pain (1), film over eye (1), light-headedness (1), bowel fullness (1), hives (1), fever (1), and oozing and hematoma formation (1). If adverse reactions are experienced, the infusion rate should be decreased, or if indicated, the infusion should be interrupted until symptoms abate.

DRUG INTERACTIONS

The anticoagulant effect of heparin is enhanced by concurrent treatment with Antithrombin III (Human), THROMBATE III in patients with hereditary AT-III deficiency. Thus, in order to avoid bleeding reduced dosage of heparin is recommended during treatment with THROMBATE III.