Pah Warnings, Precautions, Pregnancy, Nursing, Abuse - Aminohippurate

Pah Warnings, Precautions, Pregnancy, Nursing, Abuse - Aminohippurate

WARNINGS

No Information Provided.

PRECAUTIONS

General

Intravenous solutions must be given with caution to patients with low cardiac reserve, since a rapid increase in plasma volume can precipitate congestive heart failure.

For measurement of ERPF, small doses of PAH are used. However, in research procedures to measure Tm _PAH , high plasma levels are required to saturate the capacity of the tubular cells. During these procedures the intravenous administration of PAH solutions should be carried out slowly and with caution. The patient should be continuously observed for any adverse reactions.

Drug Interactions

Renal clearance measurements of PAH cannot be made with any significant accuracy in patients receiving sulfonamides, procaine, or thiazolesulfone. These compounds interfere with chemical color development essential to the analytical procedures.

Probenecid depresses tubular secretion of certain weak acids such as PAH. Therefore, patients receiving probenecid will have erroneously low ERPF and Tm _PAH values.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term studies in animals have not been done to evaluate any effects upon fertility or carcinogenic potential of PAH.

Pregnancy

Pregnancy Category C. Animal reproduction studies have not been done with PAH. It is also not known whether PAH can cause fetal harm when given to a pregnant woman or can affect reproduction capacity. PAH should be given to a pregnant woman only if clearly needed.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when PAH is administered to a nursing woman.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Geriatric Use

Clinical studies of PAH did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients.