Pah Pharmacology, Pharmacokinetics, Studies, Metabolism - Aminohippurate

Pah Pharmacology, Pharmacokinetics, Studies, Metabolism - Aminohippurate

CLINICAL PHARMACOLOGY

PAH is filtered by the glomeruli and is actively secreted by the proximal tubules. At low plasma concentrations (1.0 to 2.0 mg/100 mL), an average of 90 percent of PAH is cleared by the kidneys from the renal blood stream in a single circulation. It is ideally suited for measurement of ERPF since it has a high clearance, is essentially nontoxic at the plasma concentrations reached with recommended doses and its analytical determination is relatively simple and accurate.

PAH is also used to measure the functional capacity of the renal tubular secretory mechanism or transport maximum (Tm _PAH ). This is accomplished by elevating the plasma concentration to levels (40-60 mg/100 mL) sufficient to saturate the maximal capacity of the tubular cells to secrete PAH.

Inulin clearance is generally measured during Tm _PAH determinations since glomerular filtration rate (GFR) must be known before calculations of secretory Tm measurements can be done (See Calculations ).