Pah Side Effects, and Drug Interactions - Aminohippurate

Pah Side Effects, and Drug Interactions - Aminohippurate

SIDE EFFECTS

Hypersensitivity reactions (including angioedema and urticaria), vasomotor disturbances, flushing, tingling, nausea, vomiting, and cramps may occur.

Patients may have a sensation of warmth or the desire to defecate or urinate during or shortly following initiation of infusion.

DRUG INTERACTIONS

Renal clearance measurements of PAH cannot be made with any significant accuracy in patients receiving sulfonamides, procaine, or thiazolesulfone. These compounds interfere with chemical color development essential to the analytical procedures.

Probenecid depresses tubular secretion of certain weak acids such as PAH. Therefore, patients receiving probenecid will have erroneously low ERPF and Tm _PAH values.