A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Yocon Pharmacology, Pharmacokinetics, Studies, Metabolism - Yohimbine Hydrochloride
Yocon Pharmacology, Pharmacokinetics, Studies, Metabolism - Yohimbine Hydrochloride
CLINICAL PHARMACOLOGY
Yohimbine blocks presynaptic
alpha-2-adrenergic receptors. Its action or peripheral
blood vessels resembles that
of reserpine, though it is weaker and of short duration. Yohimbine's peripheral
autonomic nervous
system effect is to increase parasympathetic
(cholinergic) and decrease sympathetic (adrenergic) activity. It is to
be noted that in male sexual
performance, erection is linked to cholinergic
activity and to alpha-2 adrenergic
blockade which may theoretically result in increased penile
inflow, decreased penile blood outflow
or both. Yohimbine exerts a stimulating action
on the mood and may increase anxiety. Such actions have not been adequately
studied or related to dosage
although they appear to require high doses of the drug. Yohimbine has
a mild anti- diuretic action,
probably via stimulation of hypothalamic
centers and release of posterior
pituitary hormone.
Reportedly, Yohimbine exerts no
significant influence
on cardiac stimulation and
other effects mediated by beta-adrenergic receptors, its effect
on blood pressure, if any
would be to lower it; however, no
adequate studies are at hand
to quantitate this effect in
terms of yohimbine dosage.
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