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Tubersol Side Effects, and Drug Interactions - Tuberculin Purified Protein Derivative

SIDE EFFECTS

In highly sensitized individuals, strongly positive reactions including vesiculation, ulceration or necrosis may occur at the test site. Cold packs or topical steroid preparations may be employed for symptomatic relief of the associated pain, pruritus and discomfort.

Strongly positive reactions may result in scarring at the test site. Immediate erythematous or other reactions may occur at the injection site. The reason( s) for these infrequent occurrences are presently unknown.

DRUG INTERACTIONS

Reactivity to the test may be depressed or suppressed in individuals who are receiving corticosteroids or immunosuppressive agents.

Reactivity to PPD may be temporarily depressed by certain live virus vaccines (measles, mumps, rubella). Therefore, if a tuberculin test is to be performed, it should be administered either before or simultaneously with the injection of measles, mumps and rubella vaccines in combined form or as separate antigens.

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