A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Dyrenium Side Effects, and Drug Interactions - Triamterene
Dyrenium Side Effects, and Drug Interactions - Triamterene
SIDE EFFECTS
Adverse effects are listed in decreasing order
of frequency; however, the most serious adverse effects are listed
first regardless of frequency. All adverse effects occur rarely
(that is, one in 1000, or less).
Hypersensitivity: anaphylaxis,
rash, photosensitivity.
Metabolic: hyperkalemia,
hypokalemia.
Renal: azotemia,
elevated BUN and creatinine,
renal stones, acute interstitial
nephritis (rare),
acute renal
failure (one case
of irreversible renal failure
has been reported).
Gastrointestinal: jaundice
and/or liver enzyme
abnormalities, nausea and vomiting,
diarrhea.
Hematologic: thrombocytopenia, megaloblastic anemia.
Central Nervous System: weakness, fatigue,
dizziness, headache,
dry mouth.
DRUG INTERACTIONS
Caution should be used when lithium
and diuretics are used concomitantly because diuretic-induced sodium
loss may reduce
the renal clearance
of lithium and increase serum
lithium levels with
risk of lithium
toxicity. Patients receiving such
combined therapy should
have serum lithium
levels monitored closely and the lithium
dosage adjusted if necessary.
A possible interaction resulting in acute
renal failure
has been reported in a few subjects when indomethacin, a nonsteroidal
anti-inflammatory
agent, was given with triamterene. Caution is advised in administering
nonsteroidal anti-inflammatory agents with triamterene.
The effects of the following drugs may be potentiated when given
together with triamterene: antihypertensive
medication, other
diuretics, preanesthetic and anesthetic
agents, skeletal muscle
relaxants (nondepolarizing).
Potassium-sparing agents should be used with caution in conjunction
with angiotensin-converting enzyme
(ACE) inhibitors due to an increased risk of hyperkalemia.
The following agents, given together with triamterene, may promote
serum potassium accumulation and possibly result in hyperkalemia
because of the potassium-sparing nature of triamterene, especially
in patients with renal insufficiency: blood
from blood bank
(may contain up to 30 mEq
of potassium per liter
of plasma or up to 65
mEq per
liter of whole blood
when stored for more than 10 days); low-salt milk
(may contain up to 60 mEq
of potassium per liter); potassium-containing medications (such
as parenteral penicillin
G potassium); salt substitutes
(most contain substantial amounts of potassium).
Triamterene may raise blood
glucose levels; for
adult-onset diabetes, dosage adjustments of hypoglycemic agents
may be necessary during and after therapy; concurrent use with chlorpropamide
may increase the risk of
severe hyponatremia.
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