A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Retin A Side Effects, and Drug Interactions - Tretinoin (topical)
Retin A Side Effects, and Drug Interactions - Tretinoin (topical)
SIDE EFFECTS
Cream, Gel, Liquid and Gel with Microspheres: The
skin of certain sensitive
individuals may become excessively red, edematous, blistered, or
crusted. If these effects occur, the medication
should either be discontinued until the integrity of the skin
is restored, or the medication should be adjusted to a level the
patient can tolerate.
However, efficacy has not been established for lower dosing frequencies.
True contact allergy
to topical tretinoin
is rarely encountered. Temporary hyper- or hypopigmentation has
been reported with repeated application of tretinoin. Some individuals
have been reported to have heightened susceptibility to sunlight
while under treatment
with tretinoin. To date, all adverse effects of tretinoin have been
reversible upon discontinuation
of therapy (see DOSAGE AND ADMINISTRATION).
Emollient Cream: (See WARNINGS
and PRECAUTIONS).
In double-blind, vehicle-controlled studies involving 179 patients
who applied tretinoin
emollient cream
to their face, adverse reactions associated with the use of tretinoin
emollient cream
were limited primarily to the skin. During these trials, 4% of patients
had to discontinue use of tretinoin emollient cream
because of adverse reactions. These discontinuations were due to
skin irritation
or related cutaneous
adverse reactions.
Local reactions such as peeling, dry skin, burning, stinging, erythema,
and pruritus were reported
by almost all subjects during therapy with tretinoin emollient cream.
These signs and symptoms were usually of mild to moderate severity
and generally occurred early in therapy. In
most patients the dryness, peeling, and redness recurred after an
initial (24 weeks) decline.
DRUG INTERACTIONS
Concomitant topical
medication, medicated or abrasive
soaps and cleansers, products that have a strong drying effect,
products with high concentrations of alcohol, astringents, spices,
lime, or lime peel should
be used with caution because of possible interaction with tretinoin.
Particular caution should be exercised with the concomitant
use of topical over-the-counter
acne preparations containing benzoyl peroxide, sulfur, resorcinol,
or salicylic acid with tretinoin. It also is advisable to allow
the effects of such preparations to subside before use of tretinoin
is begun.
Tretinoin emollient
cream should not be administered
if the patient is also taking drugs known to be photosensitizers
(e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines,
sulfonamides) because of the possibility of augmented phototoxicity.
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