Trelstar Online, Description, Chemistry, Ingredients - Triptorelin pamoate

Trelstar Online, Description, Chemistry, Ingredients - Triptorelin pamoate

Trelstar^TMLA 11.25mg

triptorelin pamoate for injectable suspension

TRELSTAR^TM LA contains a pamoate salt of triptorelin, and trip-torelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH or GnRH) with greater potency than the naturally occurring LHRH. The chemical name of triptorelin pamoate is 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl Lleucyl-L-arginyl-L-prolylglycine amide (pamoate salt); the empirical formula is C₆₄H₈₂N₁₈O₁₃. C₂₃H₁₆O₆ and the molecular weight is 1699.9. The structual formula is:

TRELSTAR^TM LA is a sterile, lyophilized biodegradable microgran-ule formulation supplied as a single-dose vial containing triptorelin pamoate (11.25 mg as the peptide base), 145 mg poly d,l-lactide-co-glycolide, 85 mg mannitol USP, 30 mg carboxymethylcellulose sodium USP, 2 mg polysorbate 80 NF. When 2 mL sterile water for injection is added to the vial containing TRELSTAR^TM LA and mixed, a suspension is formed which is intended as an intramuscular injection to be administered every 84 days (ie, every 12 weeks). TRELSTAR^TM LA is available in 2 packaging configurations: (a) TRELSTAR^TM LA vial alone or (b) TRELSTAR^TM LA vial plus a separate pre-filled syringe that contains 2 mL of sterile water for injection, USP (Debioclip^TM).