A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Ultram Overdose, Contraindications and Information - Tramadol Hcl
Ultram Overdose, Contraindications and Information - Tramadol Hcl
OVERDOSE
Serious potential consequences of overdosage are respiratory
depression, lethargy, coma, seizure, cardiac arrest and death.(See WARNINGS.)
Fatalities have been reported in post marketing in association with both intentional
and unintentional overdose with ULTRAM. In treating an overdose, primary attention
should be given to maintaining adequate ventilation along with general supportive
treatment. While naloxone will reverse some, but not all, symptoms caused by
overdosage with ULTRAM, the risk of seizures is also increased with naloxone
administration. In animals convulsions following the administration of toxic
doses of tramadol could be suppressed with barbiturates or benzodiazepines but
were increased with naloxone. Naloxone administration did not change the lethality
of an overdose in mice. Hemodialysis is not expected to be helpful in an overdose
because it removes less than 7% of the administered dose in a 4-hour dialysis
period.
CONTRAINDICATIONS
ULTRAM should not be administered to patients who have previously
demonstrated hypersensitivity to tramadol, any other component of this product
or opioids. ULTRAM is contraindicated in any situation where opioids are contraindicated,
including acute intoxication with any of the following: alcohol, hypnotics,
narcotics, centrally acting analgesics, opioids or psychotropic drugs. ULTRAM
may worsen central nervous system and respiratory depression in these patients.
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