A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Tolinase Overdose, Contraindications and Information - Tolazamide
Tolinase Overdose, Contraindications and Information - Tolazamide
OVERDOSE
Overdosage of sulfonylureas, including TOLINASE Tablets, can
produce hypoglycemia.
Mild hypoglycemic symptoms without loss of consciousness or
neurologic findings should be treated aggressively with oral glucose and adjustment
in drug dosage and/or meal patterns. Close monitoring should continue until
the physician is assured the patient is out of danger. Severe hypoglycemic reactions
with coma, seizure, or other neurological impairment occur infrequently, but
constitute medical emergencies requiring immediate hospitalization. If hypoglycemic
coma is suspected or diagnosed, the patient should be given a rapid intravenous
injection of concentrated (50%) glucose solution. This should be followed by
a continuous infusion of a more dilute (10%) glucose solution at a rate which
will maintain the blood glucose at a level above 100 mg/dl. Patients should
be closely monitored for a minimum of 24 to 48 hours since hypoglycemia may
recur after apparent clinical recovery.
CONTRAINDICATIONS
TOLINASE Tablets are contraindicated in patients with:
1) known hypersensitivity or allergy to TOLINASE;
2) diabetic ketoacidosis, with or without coma. This condition should be
treated with insulin;
3) Type I diabetes, as sole therapy.
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