A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Tobradex Side Effects, and Drug Interactions - Tobramycin and Dexamethasone
Tobradex Side Effects, and Drug Interactions - Tobramycin and Dexamethasone
SIDE EFFECTS
Adverse reactions have occurred with steroid/anti-infective combination
drugs which can be attributed to the steroid
component, the anti-infective component, or the combination. Exact
incidence figures
are not available. The most frequent adverse reactions to topical
ocular tobramycin
are hypersensitivity and localized
ocular toxicity, including
lid itching and swelling,
and conjunctival erythema. These reactions occur in less than 4%
of patients. Similar reactions may occur with the topical
use of other aminoglycoside antibiotics. Other adverse reactions
have not been reported; however; if topical ocular
tobramycin is administered
concomitantly with systemic
aminoglycoside antibiotics, care should be taken to monitor
the total serum concentration.
The reactions due to steroid
component are: elevation
of intraocular pressure
(IOP) with possible development
of glaucoma, and infrequent optic
nerve damage; posterior
subcapsular cataract
formation; and delayed wound
healing.
Secondary Infection: The development
of secondary infection has occurred after use of combinations containing
steroids and antimicrobials. Fungal infections of the cornea
are particularly prone
to develop coincidentally with long-term applications of steroids.
The possibility of fungal invasion must be considered in any persistent
corneal ulceration
where steroid treatment
has been used. Secondary bacterial ocular
infection following
suppression of host responses
also occurs.
DRUG INTERACTIONS
No information provided.
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