A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Timoptic Online, Description, Chemistry, Ingredients - Timolol Maleate
Timoptic Online, Description, Chemistry, Ingredients - Timolol Maleate
DESCRIPTION
Timolol maleate is a non-selective beta-adrenergic receptor
blocking agent. The chemical
name for timolol maleate tablets is (S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-
1,2,5-thiadiazol -3 -yl]oxy]-2-propanol, (Z)-2-butenedioate
(1:1) salt. The chemical
name for timolol maleate ophthalmic
solutions and ophthalmic gel forming solution
is (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol
maleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon
atom in its structure
and is provided as the levo-isomer. Its empirical
formula is C13H24N4O3S•C4H4O4.
Timolol maleate has a molecular weight
of 432.50. It is a white, odorless, crystalline powder
which is soluble in
water, methanol, and alcohol.
Tablets: Blocadren is supplied as tablets in three
strengths containing 5 mg, 10 mg
or 20 mg timolol maleate
for oral administration.
Inactive ingredients are cellulose, FD&C blue
2, magnesium stearate,
and starch.
Ophthalmic Solution: Timoptic is stable
at room temperature. Timoptic
ophthalmic solution
is supplied as a sterile, isotonic, buffered, aqueous solution
of timolol maleate in two dosage
strengths: each ml of Timoptic
0.25% contains 2.5 mg of
timolol (3.4 mg of timolol
maleate). Each ml of Timoptic
0.5% contains 5.0 mg of timolol
(6.8 mg of timolol maleate).
Inactive Ingredients: Monobasic and dibasic
sodium phosphate, sodium
hydroxide to adjust
pH, and water for injection.
Benzalkonium chloride 0.01% is added as preservative.
Preservative-Free Ophthalmic Solution: Timolol maleate
is stable at room
temperature. Preservative-free ophthalmic
solution Timoptic is
supplied in Ocudose, a unit
dose container, as a sterile,
isotonic, buffered, aqueous
solution of timolol
maleate in two dosage
strengths: Each ml of preservative-free
Timoptic in Ocudose 0.25% contains 2.5 mg of timolol (3.4 of timolol
maleate). Each ml of preservative-free
Timoptic in Ocudose 0.5% contains 5.0 mg
of timolol (6.8 mg of timolol
maleate). Inactive Ingredients: Monobasic and dibasic
sodium phosphate, sodium
hydroxide to adjust pH, and water
for injection.
Ophthalmic Gel Forming Solution: Timoptic-XE sterile
ophthalmic gel forming solution
is supplied as a sterile, isotonic, buffered, aqueous solution of
timolol maleate in two dosage
strengths. Each ml of Timoptic-XE
0.25% contains 2.5 mg of
timolol (3.4 mg of timolol
maleate). Each ml of Timoptic-XE
0.5% contains 5.0 mg of timolol
(6.8 mg of timolol maleate).
Inactive Ingredients: Gelrite gellan gum, tromethamine, mannitol,
and water for injection.
Preservative: Benzododecinium bromide
0.012%.
Gelrite is a purified anionic heteropolysaccharide derived from gellan
gum. An aqueous solution
of Gelrite, in the presence of a cation, has the ability to gel. Upon
contact with the precorneal
tear film, Timoptic-XE forms
a gel that is subsequently removed
by the wflow of tears.
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