A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Sumycin Side Effects, and Drug Interactions - Tetracycline
Sumycin Side Effects, and Drug Interactions - Tetracycline
SIDE EFFECTS
Capsules
Gastrointestinal: Anorexia, epigastric distress,
nausea, vomiting, diarrhea, bulky loose stools, stomatitis, sore
throat, glossitis, black hairy tongue, dysphagia, hoarseness, enterocolitis,
and inflammatory lesions (with monilial overgrowth) in the anogenital
region, including proctitus and pruritus
ani. These reactions have been caused by both the oral and parenteral
administration
of tetracyclines.
Skin: Maculopapular and erythematous rashes. Exfoliative
dermatitis has been reported but is uncommon. Photosensitivity is
discussed above. (See WARNINGS.)
Renal toxicity: Rise in BUN
has been reported and is apparently dose related. (See WARNINGS.)
Hepatic cholestasis
has been reported rarely, and is usually associated with high dosage
levels of tetracycline.
Hypersensitivity reactions: urticaria, angioneurotic
edema, anaphylaxis, anaphylactoid purpura, pericarditis
and exacerbation
of systemic lupus erythematosus, and serum
sickness-like reactions, as fever, rash, and arthralgia.
Bulging fontanels have been reported in young infants following
full therapeutic dosage. This sign
disappeared rapidly when the drug
was discontinued.
Blood: anemia, hemolytic
anemia, thrombocytopenia, thrombocytopenic purpura, neutropenia
and eosinophilia
have been reported.
Dizziness and heachache have been reported.
When given over prolonged periods, tetracyclines have been reported
to produce brown-black microscopic discoloration of thyroid
glands. No abnormalities of thyroid
function studies are
known to occur.
Topical Solution
Among the 838 patients treated with tetracycline
topical solution
under normal usage conditions during clinical
evaluation, there was one instance of severe dermatitis
requiring systemic
steroid therapy.
About one-third of patients are likely to experience
a stinging or burning sensation. The sensation
ordinarily lasts no more than a few minutes, and does not occur
at every application. There has been no indication
that patients experience
sufficient discomfort to reduce
the frequency of use or to discontinue use of the product.
The kinds of side effects
often associated with oral
or parenteral administration
of tetracyclines (e.g., various gastrointestinal
complaints, vaginitis, hematologic abnormalities, manifestations
of systemic hypersensitivity
reactions, and dental
and skeletal disorders)
have not been observed with tetracycline topical
solution. Because this drug's topical
from of administration, it is highly unlikely that such side
effects will occur from
its use.
Ophthalmic Suspension
Dermatitis and allied symptomatology have been reported. If adverse
reaction or idiosyncrasy occurs, discontinue medication
and institute appropriate therapy.
DRUG INTERACTIONS
No infromation provided.
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