A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Sinemet Online, Description, Chemistry, Ingredients - Carbidopa-Levodopa
Sinemet Online, Description, Chemistry, Ingredients - Carbidopa-Levodopa
TABLETS
SINEMET®
(CARBIDOPA-LEVODOPA)
DESCRIPTION
SINEMET* (Carbidopa-Levodopa) is a combination of carbidopa and levodopa for the treatment of Parkinson's disease and syndrome.
Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.3. It is designated chemically as (— )-L-a-hydrazino-a-methyl-b-(3,4-dihydroxybenzene) propanoic acid monohydrate. Its empirical formula is C10H14N2O4•H20, and its structural formula is:
Tablet content is expressed in terms of anhydrous carbidopa
which has a molecular weight of 226.3.
Levodopa, an aromatic amino acid, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 197.2. It is designated chemically as (— )-L-a-amino-b-(3,4-dihydroxybenzene) propanoic acid. Its empirical formula is C9H11NO4, and its structural formula is:
SINEMET is supplied as tablets in three strengths:
SINEMET 25-100, containing 25 mg of carbidopa and 100 mg of levodopa.
SINEMET 10-100, containing 10 mg of carbidopa and 100 mg of levodopa.
SINEMET 25-250, containing 25 mg of carbidopa and 250 mg of levodopa.
Inactive ingredients are cellulose, magnesium stearate, and starch. Tablets SINEMET 10-100 and 25-250 also contain FD&C Blue 2. Tablets SINEMET 25-100 also contain D&C Yellow 10 and FD&C Yellow 6.
* Registered trademark of MERCK & CO., INC., COPYRIGHT © MERCK & CO., INC., 1996, All rights reserved
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