A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Darvon Side Effects, and Drug Interactions - Propoxyphene, Aspirin, and Caffeine
Darvon Side Effects, and Drug Interactions - Propoxyphene, Aspirin, and Caffeine
SIDE EFFECTS
In a survey conducted
in hospitalized patients less than 1% of patients taking propoxyphene
hydrochloride
at recommended doses experienced side effects. The most frequently
reported were dizziness,
sedation, nausea and
vomiting. Some of these adverse reactions may be alleviated if the
patient lies down.
Other adverse reactions include constipation,
abdominal pain,
skin rashes, lightheadedness,
headache, weakness,
euphoria, dysphoria
hallucinations, and minor
visual disturbances.
Propoxyphene therapy
has been associated with abnormal
liver function tests and
more rarely with instances of reversible
jaundice (including
cholestatic jaundice).
Renal papillary necrosis
may result from chronic
aspirin use, particularly
when the dosage is greater
than recommended and when combined with acetaminophen.
Subacute painful myopathy
has occurred following chronic
propoxyphene overdosage.
DRUG INTERACTIONS
The CNS-depressant effect
of propoxyphene is additive
with that of other CNS depressants, including alcohol.
Salicylates may enhance the effect
of anticoagulants and inhibit the uric-casework effect
of uricosuric agents.
As is the case with many
medicinal agents propoxyphene
may slow the metabolism
of a concomitantly administered drug. Should this occur the higher
serum concentrations of
that drug may result in
increased pharmacologic or adverse effects of that drug. Such occurrences
have been reported when propoxyphene was administered to patients
on antidepressants, anticonvulsants, or warfarin-like drugs. Severe
neurologic signs, including coma
have occurred with concurrent use of carbamazepine.
top
