A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Phenergan Side Effects, and Drug Interactions - Promethazine
Phenergan Side Effects, and Drug Interactions - Promethazine
SIDE EFFECTS
Injection
CNS Effects
Drowsiness is the most prominent CNS
effect of this drug. Extrapyramidal reactions may occur with high doses;
this is almost always responsive to a reduction
in dosage. Other reported reactions include dizziness, lassitude, tinnitus,
incoordination, fatigue, blurred vision, euphoria, diplopia, nervousness,
insomnia, tremors, convulsive seizures, oculogyric
crises, excitation, catatonic-like states, and hysteria.
Cardiovascular Effects
Tachycardia, bradycardia, faintness, dizziness, and increases and decreases
in blood pressure
have been reported following the use of promethazine hydrochloride
injection. Venous thrombosis at the injection
site has been reported. INTRA-ARTERIAL
INJECTION MAY RESULT IN GANGRENE OF THE AFFECTED EXTREMITY (see WARNINGS.)
Gastrointestinal
Nausea and vomiting have
been reported, usually in association
with surgical procedures
and combination drug therapy.
Allergic Reactions
These include urticaria, dermatitis, asthma, and photosensitivity. Angioneurotic
edema has been reported.
Other Reported Reactions
Leukopenia and agranulocytosis, usually when promethazine HCl has been
used in association with
other known toxic agents, have been reported. Thrombocytopenic purpura
and jaundice of the obstructive type
have been associated with the use of promethazine. The jaundice
is usually reversible on
discontinuation of the drug. Subcutaneous injection has resulted in tissue
necrosis. Nasal stuffiness may occur. Dry mouth
has been reported.
Laboratory Tests
The following laboratory tests may be affected in patients who are receiving
therapy with promethazine hydrochloride:
Pregnancy Tests: Diagnostic pregnancy tests based on immunological
reactions between HCG and anti-HCG
may result in false-negative
or false-positive interpretations.
Glucose Tolerance Test: An increase in blood
glucose has been reported
in patients receiving promethazine.
Paradoxical Reactions (Overdosage)
Hyperexcitability and abnormal
movements, which have been reported in children following a single administration
of promethazine, may be manifestations of relative overdosage, in which
case, consideration should be given to the discontinuation of the promethazine
and to the use of other drugs. Respiratory depression, nightmares, delirium,
and agitated behavior have
also been reported in some of these patients.
Syrup, Tablets and Suppositories
Nervous System: Sedation, sleepiness, occasional
blurred vision, dryness of mouth, dizziness; rarely confusion, disorientation,
and extrapyramidal
symptoms such as oculogyric
crisis, torticollis, and tongue protrusion
(usually in association
with parenteral injection
or excessive dosage).
Cardiovascular: Increased or decreased blood
pressure.
Dermatologic: Rash, rarely photosensitivity.
Hematologic: Rarely leukopenia, thrombocytopenia;
agranulocytosis (1 case).
Gastrointestinal: Nausea and vomiting.
DRUG INTERACTIONS
Injection
Narcotics And Barbiturates: The CNS-depressant effects
of narcotics are additive
with promethazine hydrochloride.
Monoamine Oxidase Inhibitors (Maoi): Drug interactions,
including an increased incidence
of extrapyramidal
effects, have been reported when some MAOI and phenothiazines
are used concomitantly. Although such a reaction
has not been reported with promethazine, the possibility should
be considered.
Syrup, Tablets and Suppositories
The sedative action
of promethazine is additive
to the sedative effects
of other central nervous
system depressants, including
alcohol, narcotic analgesics, sedatives, hypnotics, tricyclic antidepressants,
and tranquilizers; therefore, these agents should be avoided or
administered in reduced dosage to patients receiving promethazine.
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